The Saint Louis University Macelwane Hall Renovation involved a complete overhaul of all floors following a fire that caused the facility’s temporary closure. The revitalized building strengthens the connection between the University's North and South campuses, supporting greater research collaboration while fitting seamlessly into the campus’s broader master plan. The renovated facility plays a key role within the University’s research precinct, enhancing the academic and scientific landscape of the campus.

The updated Macelwane Hall now houses a variety of spaces to support both teaching and research activities. It includes lower- and upper-division teaching laboratories, research labs, classrooms, administrative and faculty offices, student gathering areas, and common and support spaces. Specialized facilities such as a bioinformatics/computation lab, aquatics laboratory, and a plant growth chamber are located on the first floor, while the second floor offers classrooms, offices, and additional laboratories. The third floor features laboratories equipped for biochemistry, molecular technology, neuroscience, physiology, and genetics research.

To further support the student experience, the renovation added study and lounge spaces that encourage collaboration and social interaction. Sustainability was also a priority throughout the project, with the renovated building exceeding the City of St. Louis’ energy code requirements and incorporating a variety of sustainable design and construction strategies. The result is a modern, high-performing academic building that supports both current and future generations of students and researchers.